This publication summarises a Novartis-sponsored breakfast symposium presentation by Professor
Andrew Sindone, held in June 2023, in Auckland at the Cardiac Society of Australia and New Zealand
Annual Scientific Meeting. In this symposium, Professor Sindone provided a summary of international
heart failure guidelines for starting the four pillars of heart failure therapy – angiotensin receptor/neprilysin inhibitors (ARNIs), beta-blockers, mineralocorticoid receptor antagonists (MRA) and sodium-glucose cotransporter-2 (SGLT2) inhibitors – and rapidly up-titrating these agents. He provided a brief overview of why use of the ‘fantastic four’ is important in heart failure and how to implement such therapy. The complete CSANZ symposium presentation video can also be viewed here.
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